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Excited to share our work Journal of Cell Biology! We find that chromosome size-dependent spindle forces impair mammalian mitotic error correction of long chromosomes. Congrats to graduate student Megan K Chong who led this work! With Miquel miquel rosas salvans Vanna Tran rupress.org/jcb/article/22…

What is the origin of our body? Our paper Cell shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta. cell.com/cell/fulltext/…

Excited to share our new work!!🥳How do cells lose totipotency to fate segregation? w Zernicka-Goetz Lab we found that early blastomeres experience a "Composite State" by displaying dual-lineages signatures! Link for full text👉: rdcu.be/dITfo

I am very excited to share our lab's first manuscript! In 2020, we published that the mouse ovary becomes stiffer with advanced maternal age. In my lab, we decided to investigate the biological significance of this discovery 1/12 biorxiv.org/content/10.110…

Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long? Our latest research in Nature Cell Biology reveals that oocyte maintenance involves exceptional protein longevity. nature.com/articles/s4155… (1/9)

Excited to share our work Journal of Cell Biology! We find that torques within and outside the spindle oppose each other to limit spindle twist during anaphase. Congrats to Lila Neahring who led the work! Thanks to Nathan Cho, Caleb Rux, Ahmet Yildiz, Upadhyayula and Subramanian Labs.

A recent study from the Duncan Lab on long lived proteins in the ovary and oocyte was featured in Science! science.org/content/articl… Read the full paper: elifesciences.org/reviewed-prepr…

Congratulations to Inwon Lee for some great observations and beautiful movies. When investigating how mitochondria move in eggs and embryos, we found Trak2 caused aggregation into 'mitoballs'. Nuclear position, shape and function were all disrupted and embryos failed to develop.

Thrilled to share I will be joining the Department of Cell and Dev. Bio. CU Anschutz Medical Campus as an Assistant Professor starting Jan 2025! My lab will investigate the mechanisms that regulate genome integrity and how these processes are rewired across disease, development, and evolution

Excited to share the publication of 'Molecular Mechanisms Determining Mammalian Oocyte Quality', edited by me, including outstanding chapters from Karen Schindler Dr. Karen Schindler, Jennifer Wood Jennifer Wood, Joe Qiao, So-Youn Kim So-Youn Kim and Mike Lampson, and their teams.

🚨New preprint on “decoupling the peri-centromere from the kinetochore” in Peromyscus mice🐭 Congrats to our postdoc Eddie Pan for leading this work together with Melania Bruno in Todd Macfarlan lab! biorxiv.org/content/10.110…

The latest from Quinn Hoorn - the paper was designated Editor's Choice by Biology of Reproduction. Thanks everyone involved. Machine learning to identify endometrial biomarkers predictive of pregnancy success following artificial insemination in dairy cows† academic.oup.com/biolreprod/art…

Woohoo, it's out! Our exciting publication in PNASNews on genetic variants in kinesin genes that alter egg aneuploidy in humans. pnas.org/doi/10.1073/pn…

Thank you very much, Gabriele!

Oocytes are arrested in prophase to give them enough time to grow and accumulate sufficient maternal components.🥚 Our Nature Communications study led by Shiya Cheng reveals two mechanisms repressing cyclin B1 translation to maintain this arrest. bit.ly/4fVHgMz (1/6)

if you are interested: Hansen IETS Pioneer Award youtu.be/H2L70EFtduA?si… via YouTube

I am thrilled to share our new review on holocentric chromosomes. It was a lot of fun to write it together with Ines Drinnenberg! Same but different: Centromere regulations in holocentric insects and plants sciencedirect.com/science/articl…

📣 Paper alert!! Excited to share the 2nd research paper from my time in the BökeLab at Centre for Genomic Regulation (CRG), out today in the The EMBO Journal! We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?" We collaborated with Dexeus Mujer and employed