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Where in the World Does Lightning Strike the Most? images.app.goo.gl/WTQ4g2NHNQEe3m…

US reports 1st outbreak of 'highly pathogenic' H5N9 virus in poultry. Should we worry? livescience.com/health/flu/us-…

CTCF-Related Syndrome simonssearchlight.org/gene-guide/ctc… via @S_Searchlight

Tumor-associated zinc finger CTCF mutations which selectively alter its DNA-binding specificity have been reported for the first time by Galina Filippova et. al. almost 25 years ago: pubmed.ncbi.nlm.nih.gov/11782357/

Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter its DNA-binding specificity. Filippova et al Cancer Res Jan 1; 62(1): 48-52 (2002). pubmed.ncbi.nlm.nih.gov/11782357/

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites Genome Biol. 2024 Jan 31; 25(1): 40. pubmed.ncbi.nlm.nih.gov/38297316/ genomebiology.biomedcentral.com/articles/10.11…

Familial cases of point mutations in the XIST promoter which revealed strict correlation between CTCF binding and preemptive choices of X chromosome inactivation have already provided near direct evidence for the crucial CTCF role in Human X-inactivation pubmed.ncbi.nlm.nih.gov/15731119/

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma PNAS U S A. 2002 May 14; 99(10): 6806-11 pnas.org/doi/10.1073/pn…

Post-fertilization initiation of anti-sense transcript in ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2 in rabbits and macaques eLIFE publication (June 2, 2025) by Hisato Kobayashi, corresponding author and 22 coauthors doi.org/10.7554/eLife.…

CTCF-binding silencer in the WT1 anti-sense regulatory region (WT1 ARR) regulates imprinting of AWT1 and WT1-AS genes, and exhibits sequential epigenetic defects during Wilms’ tumor genesis Hum Mol Genet 2007 paper by Anne Hancock and coauthors from V. Lobanenkov & K. Malik labs

Deciphering the role of RNA in regulating DNA binding CTCF affinity in chromatin Genome Biology paper (May 12, 2025) published by Judith Hyle et al. doi.org/10.1186/s13059…

CTCF maintains pericentromere function and mitotic fidelity Preprint posted on bioRxiv (June 3, 2025) by Erin Walsh and Andrew Daniel Stephens doi.org/10.1101/2025.0…

New moon of June 2025 sees Mercury climb to its highest point in the sky space.com/stargazing/new…

CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation M. Tajmul, D. N. Bhatt, L. Ruje, E. Price, Y. Ji, D. Loukinov, V. B. Teif, V. V. Lobanenkov, E. M. Pugacheva revised May 23, 2025 biorxiv.org/content/10.110…

DeepMind’s new AlphaGenome AI takes long (1MB) stretches of DNA to predict various properties such as the expression levels of the genes they contain, how those levels could be affected by mutations, and even 3D DNA loops of enhancer-promoter links, etc. deepmind.google/discover/blog/…

Here is a wjla.com article that you might also like: wjla.com/good-morning-w…