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Microscopy—critical to biomedicine—generates large volumes of complex data that pose significant computational challenges. We’re excited to announce funding for open-source software efforts to improve image analysis and visualization: chanzuckerberg.com/newsroom/czi-a…

Directed Evolution (DE) is an optimization algorithm for proteins, so Machine Learning (ML) should help! We show on a large fitness landscape that DE+ML improves proteins better than DE alone and provide an example application. arxiv.org/abs/1902.07231 Frances Arnold Jennifer Kan

FPbase is published in Nature Methods! So very thrilled to see what started as a fun side project get released today in one of my favorite journals. Thank you Rita Strack for the encouragement. nature.com/articles/s4159…

Very happy that our manuscript on the #PlotsOfData web tool is out in PLOS Biology. Here's a link to the paper: journals.plos.org/plosbiology/ar… And the app: huygens.science.uva.nl/PlotsOfData/ Some examples of #dataViz made with PlotsOfData:

Here's to upcoming 3 month at Janelia!!!

Our preprint of turning nanobodies "on" and "off" is out! #bioRxiv Chemogenetic control of nanobodies biorxiv.org/content/10.110…

We’ve been playing around with eFRET GEVIs and figured out how to flip the signal. We made the first bright, positive-going GEVI with sub-millisecond response kinetics. Check out the preprint and let us know what you think: biorxiv.org/content/10.110… HHMI | Janelia @Abdelfattah__A

'I try to read the minds of mice' - it is #WorldBrainDay today and we want you to meet Julien Hiblot! He develops #biosensors to better understand how the brain works. Magnus Huppertz Stefanie Kühn #WelttagdesGehirns mr.mpg.de/14316918/inter…

📢#jobs Our Department of Chemical Biology lead by Kai Johnsson is looking for postdocs. The goal of the project is the development of lead compounds against new nociceptor-selective protein targets suitable for #pain #therapy. Apply now! mr.mpg.de/14404882/job_f…

🧪 Request a reagent! You would like to try out a biosensor, biomarker, etc. from our Department of Chemical Biology for one of your experiments? 📨Just send an e-mail to [email protected]. mr.mpg.de/13943495/chemi…

HOTTOP Mondays are the best! Julien Hiblot sharing ideas on his research projects.💡

Looking for a postdoc in drug development 💊 or bioengineering and microfluidics? Apply now to one of the open positions at our Department for Chemical Biology with our director Kai Johnsson! mr.mpg.de/career/job_boa…

My first tweet ever to guide you to our new pre-print about a side-by-side kinetic and structural characterization of HaloTag7, SNAP-tag and CLIP-tag. Now available on biorxiv!! biorxiv.org/content/10.110…

New far-red fluorescent Calcium indicators! Based on our fluorogenic MaP-dye strategy, we have developed calcium indicators that can easily be localised to your favourite HaloTag7-fusions. Just add MaPCa to medium and start imaging; no washing required. biorxiv.org/content/10.110…

Do you want to change the color of your biosensor on demand? Still have a large dynamic range? Check our preprint on ChemoX! More about it in the thread! (1/7) Congratulation to the team, in particular the twitterless Lars Hellweg. biorxiv.org/content/10.110…

Game on

What a nice way to finish the week! 🎉Our latest paper is now available online in Nature Chemical Biology. 📚🔬If you missed the pre-print and like biosensors, explore our innovative approach for designing and developing chemogenetic sensors. 💡Check it out here: nature.com/articles/s4158….

As part of my PhD thesis Wolfgang Wick 🇪🇺 lab DKFZ, Universitätsklinikum Heidelberg, Uni Heidelberg, @HdNeurooncology we investigated the cellular and molecular composition of tumor microtube networks in #Glioblastoma (1/6) The manuscript is hot off the press Nature Communications: nature.com/articles/s4146…